American Statistical Association
New York City
Metropolitan Area Chapter

Levin Lecture Series: Spring 2019 Colloquium Seminars
Department of Biostatistics
Mailman School of Public Health
Columbia University



TOWARDS A BIOLOGY OF RESILIENCE AND HEALTH:
A PUBLIC HEALTH PARADIGM

by

Karen Bandeen-Roche, Ph.D.
Professor and Chair at Department of Biostatistics
Johns Hopkins University

Host: Linda P. Fried, M.D., M.P.H.


Abstract

Recent advances in low-cost metagenomic and amplicon sequencing techniques enable routine sampling of environmental and host-associated microbial communities across different habitats. The data produced by these large-scale surveys typically comprise relative abundances (or compositions) of microbial taxa at different taxonomic levels. To investigate the dependency of additional covariate measurements such as metabolites or host phenotypes on the microbial compositions we introduce a general robust regression framework for compositional data. We propose a novel log-contrast regression model with mean shift parameters that allows the identification of sample outliers and maintains sub-compositional coherence with respect to the associated phylogenetic tree. The model is estimated using a sparse penalized regression approach that simultaneously enforces sparsity in mean shift and covariate parameters. We demonstrate the superiority of our approach using a wide range of synthetic simulation scenarios and infer novel associations between body mass index measurements and human gut microbes on a large public collection of human gut microbiome data.


Date: Thursday, January 24, 2019
Time: 11:45 A.M. - 12:45 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
AR Building
8th Floor Auditorium
New York, New York

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