American Statistical Association
New York City
Metropolitan Area Chapter

Mailman School of Public Health
Columbia University
Department of Biostatistics Colloquium



STATISTICAL ISSUES IN DISTINGUISHING
SECOND PRIMARY CANCERS FROM METASTASES

by

Colin Begg
Memorial Sloan-Kettering Cancer Center


Abstract

In recent years numerous investigators have conducted genetic studies of pairs of tumor specimens from the same patient to determine whether the tumors share a clonal origin. These studies have the potential to be of considerable clinical significance, especially in clinical settings where the distinction of a new primary cancer and metastatic spread of a previous cancer would lead to radically different indications for treatment. Studies of clonality have typically involved comparison of the patterns of somatic mutations in the tumors at candidate genetic loci to see if the patterns are sufficiently similar to indicate a clonal origin. More recently, some investigators have explored the use of array CGH for this purpose. In this talk new statistical approaches to this problem will be presented that are suited to each of these types of data, along with the results of studies to examine the validity of the methods.


Date: Thursday, February 8, 2007
Time: 4:00 to 5:00 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Judith Jansen Conference Room (Room 425)
New York, New York

RESERVATIONS ARE NOT REQUIRED

Refreshments will be served at 3:30 P.M. in the
Biostatistics Conference Room (Room 627).


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