American Statistical Association
New York City
Metropolitan Area Chapter

Levin Lecture Series: Fall 2019 Colloquium Seminars
Department of Biostatistics
Mailman School of Public Health
Columbia University



DISSECTING THE GENETIC ARCHITECTURE OF COMPLEX DISEASES
THROUGH GENOME-WIDE ASSOCIATION STUDIES

by

Dr. Hongyu Zhao
Chair and Ira V. Hiscock Professor, Department of Biostatistics
Yale School of Public Health

Host: Zhezhen Jin


Abstract

Genome-wide association study (GWAS) has been a great success in the past decade with thousands of chromosomal regions in the human genome implicated for hundreds of complex diseases. A typical GWAS involves thousands to hundreds of thousands individuals, each queried at over millions of sites in the human genome. Despite successes, significant challenges remain in both identifying new risk loci and interpreting results from these large data sets. In this presentation, I will describe our recent efforts to develop statistical methods, theories, and resources to infer the genetic architecture of complex disease, such as the proportion of phenotypic variations explained by genetic variations, the tissue and cell-type origin of diseases, and genetic correlations among phenotypes. The effectiveness of our methods will be demonstrated through their applications to GWAS results for a large number of traits/diseases.

This is joint work with Can Yang, Jiming Jiang, Qiongshi Lu, Debashis Paul, Wei Jiang, Cecilia Dao, and others.


Date: Thursday, September 12, 2019
Time: 11:45 A.M. - 12:45 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
AR Building
8th Floor Auditorium
New York, New York

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