American Statistical Association
New York City
Metropolitan Area Chapter

Levin Lecture Series: Fall 2018 Colloquium Seminars
Department of Biostatistics
Mailman School of Public Health
Columbia University



INTERVAL DOSE-FINDING DESIGNS:
FROM MODEL-BASED TO MODEL-FREE?

by

Yuan Ji
Professor
Department of Public Health Sciences
The University of Chicago

Host: Dr. Codruta Chiuzan


Abstract

In this talk, I will introduce a set of interval dose-finding designs, including the mTPI, mTPI-2, BOIN, and Keyboard designs. I will provide a theoretical and practical overview of these methods, their frequentist performance, and the pros and cons when compared to standard designs such as 3+3. Model-based designs such as CRM and BLRM will also be discussed. Finally, a new design, called the i3+3 design will be introduced, which is completely model-free. The i3+3 design stands for the interval 3+3 design, which uses a set of simple rules for dose escalation. The performance of the i3+3 design is compared with the interval designs, the 3+3 design, and the CRM and BLRM designs. A new metric to summarize the operating characteristics into a single value is used to evaluate all the designs.


Date: Thursday, October 4, 2018
Time: 11:45 A.M. - 12:45 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
AR Building
8th Floor Auditorium
New York, New York

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