American Statistical Association
New York City
Metropolitan Area Chapter

The Levin Lecture Series
Department of Biostatistics
Columbia University



BUMP HUNTING IN THE EPIGENOME

by

Rafael Irizzary, Ph.D.
Professor, Department of Biostatistics
Johns Hopkins University
rafalab.jhsph.edu/

Host: Dr. Srikesh Arunajadai


Abstract

In this talk, I will first give a brief introduction sharing my views on the potential leadership role that statisticians can play in the current measurement revolution. Then I will give a short tutorial on epigenetics and DNA methylation. Finally, I will describe new challenges for statisticians related to the existing field of bump hunting. I will describe the important role modern statistical techniques play in finding regions of the genome that are consistently different between disease and normal groups using both microarray and next-generation sequencing data. I will also describe the batch effect and how we deal with it.

Biographical Note

Dr. Irizarry received his bachelor’s in mathematics in 1993 from the University of Puerto Rico and went on to receive a Ph.D. in statistics in 1998 from the University of California, Berkeley. His thesis work was on Statistical Models for Music Sound Signals. He joined the faculty of the Department of Biostatistics in the Bloomberg School of Public Health in 1998 and was promoted to Professor in 2007. For the past ten years, Dr. Irizarry’s work has focused on Genomics and Computational Biology problems. In particular, he has worked on the analysis and pre-processing of microarray, second-generation sequencing, and genomic data. He is currently interested in leveraging his knowledge in translational work, e.g. developing diagnostic tools and discovering biomarkers.


Date: Thursday, October 13, 2011
Time: 4:00 - 5:00 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Biostatistics Computer Lab
6th Floor - Room 656
New York, New York

RESERVATIONS ARE NOT REQUIRED

Informal tea at 3:40 P.M.


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