American Statistical Association
New York City
Metropolitan Area Chapter

The Levin Lecture Series
Department of Biostatistics
Columbia University



DESIGN AND ANALYSIS OF GROUP-RANDOMIZED
AND INDIVIDUALLY RANDOMIZED GROUP-TREATMENT TRIALS

by

David Murray, Ph.D.
Chair and Professor, Department of Epidemiology
Ohio State University
cph.osu.edu/biopage2.cfm?id=1

Host: Dr. Roger Vaughan


Abstract

Interventions often involve planned interactions among participants post randomization. Where such interaction occurs in pre-existing groups randomized to study conditions, we have a group-randomized trial. Where such interaction occurs in groups created for the study and following individual randomization, we have an individually randomized group-treatment trial. Such trials face design and analytic challenges not found in the more familiar randomized clinical trial. This presentation will review the design and analysis of both group-randomized and individually randomized group-treatment trials. It will also compare these designs to other designs that have been suggested as less expensive alternatives including fractional factorial designs, multiple baseline designs, time series designs, quasi-experimental designs, dynamic wait list or stepped wedge designs, and regression discontinuity designs. While there are limited circumstances in which one of these alternatives may be preferred, in general the group-randomized and individually randomized group-treatment trials remain the most efficient and rigorous comparative designs available to evaluate these interventions.

Biographical Note

Dr. Murray has spent his career evaluating intervention programs designed to improve the public health. He has worked with all age groups, in a variety of settings, and with a variety of health behaviors and disease outcomes. In particular, Dr. Murray has focused on the design and analysis of group-randomized trials in which identifiable social groups are randomized to conditions and members of those groups are observed to assess the effect of an intervention. Dr. Murray wrote the first textbook on that material, published by Oxford University Press in 1998. He is actively involved in many of these trials, collaborating with colleagues around the country on their design, implementation and evaluation. He also conducts research to develop and test new methods for their analysis. Dr. Murray recently completed a two-year term as Chair of the Community-Level Heath Promotion study section at NIH.


Date: Thursday, October 20, 2011
Time: 4:00 - 5:00 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Hess Commons, L1010
New York, New York

RESERVATIONS ARE NOT REQUIRED

Informal tea at 3:40 P.M.


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