American Statistical Association
New York City
Metropolitan Area Chapter

Mailman School of Public Health
Columbia University
Department of Biostatistics Colloquium



COMPOSITE LIKELIHOOD: SOME BIOMEDICAL APPLICATIONS

by

Professor Kung-Yee Liang
Department of Biostatistics
Johns Hopkins University
Bloomberg School of Public Health


Abstract

In the past several decades, composite likelihood has drawn a good deal of attention as a tool for statistical inference, although the idea was carried out under different names such as pseudo-likelihood and independent likelihood. This approach is particularly appealing when the full log-likelihood function is difficult to compute and/or far from being normal. For the latter, the adequacy of asymptotic approximation for the maximum likelihood estimate maybe in doubt especially when there are additional nuisance parameters to deal with. Composite likelihood approach has the additional advantage for being more robust in that fewer assumptions, compared to the full likelihood approach, are needed to carry out the inference. In this talk, the points noted above are illustrated through a series of examples we have encountered in the past. In addition, we will present in details how composite likelihood approach maybe applied to case-control studies with ordinal disease categories. A genetic association study of schizophrenia will be presented for illustration.


Date: Thursday, November 6, 2008
Time: 4:00 - 5:00 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Biostatistics Computer Lab
6th Floor - Room 656
New York, New York

RESERVATIONS ARE NOT REQUIRED

Refreshments will be served at 3:30 P.M. in the
Biostatistics Conference Room (R627).


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