American Statistical Association
New York City
Metropolitan Area Chapter

Mailman School of Public Health
Columbia University
Department of Biostatistics Colloquium



MODELING GENE EXPRESSION VARIABILITY
FOR PREDICTION IN DISEASE POPULATIONS

by

Hector Corrada Bravo, Ph.D.
Department of Computer Science
University of Maryland
www.cs.umd.edu/faculty/bios/bravo.shtml


Abstract

Predictive models of disease based on gene expression measurements have focused on finding distinct representative profiles for healthy and diseased populations. However, some diseases, such as cancer, exhibit increased heterogeneity in the disease population. This is further complicated in gene expression, and other genomic assays, where means and variances are not independent. In this talk, we discuss how profiles (mean estimates), and heterogeneity (variability estimates) behave in cancer and their effect on predictive models.

Biographical Note

Hector Corrada Bravo is Assistant Professor at the Center for Bioinformatics and Computational Biology and the Department of Computer Science at the University of Maryland. He works on statistical and machine learning methods for high-throughput genomic data analysis, currently focusing on second-generation sequencing and epigenetics. Previously, he was a postdoctoral fellow in the Biostatistics department of the Johns Hopkins Bloomberg School of Public Health. His research interests span the full range of computational genomics: from pre-processing of high-throughput biological assays to disease predictive and prognostic models that integrate high-throughput genomic and other data.


Date: Thursday, December 16, 2010
Time: 4:00 - 5:00 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Biostatistics Computer Lab
6th Floor - Room 656
New York, New York

RESERVATIONS ARE NOT REQUIRED

Informal tea at 3:40 P.M.


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