American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Yuelin Li
Department of Epidemiology & Biostatistics
Memorial Sloan-Kettering Cancer Center

LATENT REGRESSION GRADED RESPONSE MODELING
FOR LINKING SNPS WITH CHEMOBRAIN

The phrase "chemo brain" has been used by cancer survivors to describe losses in memory, concentration, and other neurocognitive functioning after chemotherapy. Evidence shows that the ApoE4 allele is associated with such losses. We further extended our search to 42 other SNPs identified through candidate genes. A Latent Regression Graded Response Model (LRGRM) was carried out to link the SNPs to breast cancer survivors' latent propensity to exhibit cognitive impairment after chemotherapy. The presentation will cover the theory, implementation (using R and WinBUGS), and an example application. We aim to provide enough practical information so that LRGRM is immediately usable in your own research.


Date: Wednesday, January 12, 2011
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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