American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Ronglai Shen, Ph.D.
Assistant Attending Biostatistician
Memorial Sloan-Kettering Cancer Center

COMMON ONCOGENIC PATHWAYS UNDERPINNING
THE PREDICTION CONCORDANCE
OF SEVERAL BREAST-CANCER GENE-SIGNATURES

A recent study has shown prediction concordance of five breast-cancer gene-signatures despite minimal overlap of the component genes. We studied the similarity of these gene-signatures on the basis of the enriched functional “modules” including metabolic and signaling pathways and a set of literature-defined concepts. Common “oncogenic” attributes were identified by intersecting the top-ranking pathways overrepresented in these signatures. The significance of such overlap was assessed using a resampling-based procedure.


Date: Wednesday, January 16, 2008
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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