American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Robert J. Klein, Ph.D.
Assistant Member
Cancer Biology & Genetics
Sloan Kettering Institute

DISEQUILIBRIUM IN GENOME-WIDE ASSOCIATION STUDIES

Epidemiological studies of cancer make it clear that there is a hereditary component to cancer risk. However, traditional linkage analysis has only been able to discern the genes and mutations underlying a portion of this heritability. Recent advances in genotyping technology enables a new kind of study - genome-wide association studies. The ability to perform these studies on a true genome-wide basis relies on linkage disequilibrium that exists between SNPs as a result of the genetic history of humanity. Recent discoveries on the genetics of age-related macular degeneration illustrate both the potential and the pitfalls of discovering associated mutations indirectly through linkage disequilibrium. Linkage disequilibrium also needs to be considered when computing the power of genome-wide association studies. Misestimating the LD between SNPs in a population could lead to large misestimates of the power of a study.


Date: Wednesday, January 17, 2007
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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