American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Computational Oncology
Biostatistics Seminar Series


JJ Gao, Ph.D.
Computational Oncology

IDENTIFICATION AND INTERPRETATION OF
ONCOGENIC MUTATIONS USING 3D PROTEIN STRUCTURES

Many mutations in cancer are of unknown functional significance. Computational and statistical methods are developed to assess significantly mutated genes and hotspots. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in clusters of spatially close residues in protein structures. By applying to large-scale cancer genomics data, we identified many rare mutations as potentially functional and experimentally validated several in RAC1 and MAP2K1/MEK1. We are also working on using molecular dynamics simulation to analyze the influences of mutations on the protein structure of MEK1 and some preliminary results will be presented.


Date: Wednesday, January 24, 2018
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
Conference Room B (2nd Floor)
New York, New York

**Outside visitors please email nearyp@mskcc.org for building access. You must be on the security list to enter the floor.

The World of Statistics
Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Page last modified on January 24, 2018
Copyright © 1998-2018 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to nycasa@nycasa.org