American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Irina Ostrovnaya
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

TESTING CLONALITY OF THREE AND MORE TUMORS
USING THEIR LOSS OF HETEROZYGOSITY PROFILES

Cancer patients often develop multiple malignancies that may be either metastatic spread of a previous cancer or new primary cancers. This distinction is of considerable clinical and biological significance. If diagnosis cannot be made easily on the basis of pathology review, the patterns of somatic mutations in the tumors can be compared. Previously we developed statistical methods for testing clonality of two tumors using their loss of heterozygosity (LOH) profiles at several candidate markers. In this talk, I will discuss how to extend these methods to three and more malignancies from the same patient. Non-parametric and parametric methods will be considered, and I will present the results of simulation studies.

This is work in progress done jointly with Colin Begg.


Date: Wednesday, January 27, 2010
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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