American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Chaya S. Moskowitz, Ph.D.
Assistant Attending Biostatistician
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

STATISTICAL METHODS FOR EVALUATING THE REPRODUCIBILITY
OF SOLID TUMOR MEASUREMENTS USED IN RESPONSE ASSESSMENT

Serial tumor measurements are frequently used to assess whether cancer patients have responded to a therapeutic agent. Imprecise tumor measurements have the potential to cause erroneous conclusions in clinical trials studying new therapies and to lead to incorrect decisions in individual patient management. Repeatability and reproducibility are two standard measures of precision. There are no widely-accepted statistics, however, for quantifying either repeatability or reproducibility. In this talk, we will review methods that have been used in the radiology literature to evaluate the repeatability and reproducibility of tumor measurements. Following this review we will explore some additional methods that may be useful for this purpose. The methods will be illustrated using data prospectively collected on 32 patients with non-small cell lung cancer who agreed to undergo a repeat CT scan for research purposes.


Date: Wednesday, January 28, 2009
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Copyright © 2009 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to nycasa@mindspring.com