American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Ian McKeague
Department of Biostatistics
Columbia University

FRACTALS WITH POINT IMPACT IN FUNCTIONAL REGRESSION:
AN APPLICATION TO GENE EXPRESSION DATA

This talk introduces a class of point impact regression models in which the trajectory of a continuous stochastic process, when evaluated at one or more locations, is associated with a scalar response. A motivation for developing this type of model arises from genome-wide expression studies in which it is of interest to locate genes associated with clinical outcomes. The observed trajectories are assumed to have fractal properties (fractional Brownian motion) in the neighborhood of the targeted location. Bootstrap confidence intervals for these points are developed. Non-Gaussian limit distributions and faster-than-root-n rates of convergence that depend on the Hurst exponent of the fractional Brownian motion play a central role.


Date: Wednesday, February 10, 2010
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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