American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
Biostatistics Seminar Series

Kristen Cunanan, Ph.D.
Department of Epidemiology and Biostatistics
Memorial Sloan Kettering Cancer Center


Recent oncology clinical trials are saturated with the development of targeted therapies. This has led to a growing interest in a class of designs called "basket trials", whereby treatment allocation is biomarker-driven rather than disease-driven. In these studies, investigators are essentially screening for specific populations, i.e. baskets, that respond to an experimental drug or combination of drugs. Previously, we developed a model-free, aggregation approach for such a trial setting, whereby baskets are either treated as independent or aggregated after an interim assessment of heterogeneity of the current response rates across all baskets (Statistics in Medicine, 2017). In this work, we evaluated a popular modeling approach using Bayesian hierarchical modeling, as presented by Berry et al. (Clinical Trials, 2013). During our efforts to calibrate and compare the operating characteristics of the two designs, we found some interesting artifacts of the proposed prior. Most notably, our results suggest the proposed inverse gamma prior is strongly favorable toward declaring homogeneity of the response rates across all baskets; thus, producing a very high overall false positive rate when the drug works in some or even most baskets, but not in all or none of the baskets. In this talk, I will present the results from this investigation and discuss the advantages and disadvantages of model-free versus model-based designs.

Date: Wednesday, February 15, 2017
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor, Conference Room B
New York, New York

**Outside visitors please email for building access.
You must be on the security list to enter the floor.

The World of Statistics
Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Page last modified on February 10, 2017
Copyright © 1998-2017 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to