American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



John Storey
Department of Molecular Biology
Princeton University

CHALLENGES IN THE ANALYSIS OF CLINICAL GENOMICS STUDIES

Over the course of several years, we have carried out an analysis of a large-scale study on 168 blunt-force trauma patients over 28 days, measuring ~400 clinical variables and longitudinal gene expression with ~800 microarrays. The aim of this study is to improve our ability to diagnose and treat inflammatory complications in critically injured patients. In this talk, I will describe the challenges we have faced in analyzing these data, and some of the methodological developments we have made in addressing these challenges. I will specifically discuss methods for dealing with latent structure in gene expression data and approaches for modeling the data in such a way that confounding sources of variation are eliminated. The advances we have made from this study will likely be applicable to future large-scale clinical genomics studies, and they have directly motivated more general developments we have made in large-scale inference methods.


Date: Wednesday, February 16, 2011
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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