American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Adam B. Olshen, Ph.D.
Associate Attending Biostatistician
Memorial Sloan-Kettering Cancer Center

SEGMENTATION OF ARRAY CGH DATA
WITH APPLICATION TO
ALLELE SPECIFIC COPY NUMBER AND COPY NUMBER VARIATION

Cancer progression often involves alterations in DNA sequence copy number. Multiple microarray platforms now facilitate high-resolution copy number assessment of entire genomes in single experiments. This technology is generally referred to as array comparative genomic hybridization (array CGH). I will discuss our technique for identifying regions of abnormal copy number in array CGH data, which is called circular binary segmentation (CBS). The first published version of CBS was criticized for being slow. I will present our methods for greatly speeding up the procedure. Recently, copy number platforms have been developed from which it is possible to estimate copy number separately by parental chromosome. I will introduce procedures for making these estimates. Finally, I will discuss methods for separating copy number aberrations that are due to cancer from copy number variations that are found in the germ-line.

This is joint work with Venkat Seshan and Irina Ostrovnaya.


Date: Wednesday, February 20, 2008
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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