American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
Biostatistics Seminar Series


Kay See Tan, Ph.D.
Department of Epidemiology and Biostatistics
Memorial Sloan Kettering Cancer Center

PREDICTING NON-SMALL CELL LUNG CANCER PROGNOSIS
BY FULLY AUTOMATED MICROSCOPIC PATHOLOGY IMAGE FEATURES

(http://www.nature.com/articles/ncomms12474)

By: Kun-Hsing Yu, Ce Zhang, Gerald J. Berry, Russ B. Altman,
Christopher Ré, Daniel L. Rubin & Michael Snyder

Lung cancer is the most prevalent cancer worldwide, and histopathological assessment is indispensable for its diagnosis. However, human evaluation of pathology slides cannot accurately predict patients' prognoses. In this study, we obtain 2,186 hematoxylin and eosin stained histopathology whole-slide images of lung adenocarcinoma and squamous cell carcinoma patients from The Cancer Genome Atlas (TCGA), and 294 additional images from Stanford Tissue Microarray (TMA) Database. We extract 9,879 quantitative image features and use regularized machine-learning methods to select the top features and to distinguish shorter-term survivors from longer-term survivors with stage I adenocarcinoma (P < 0.003) or squamous cell carcinoma (P = 0.023) in the TCGA data set. We validate the survival prediction framework with the TMA cohort (P < 0.036 for both tumor types). Our results suggest that automatically derived image features can predict the prognosis of lung cancer patients and thereby contribute to precision oncology. Our methods are extensible to histopathology images of other organs.


Date: Wednesday, March 8, 2017
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor, Conference Room B
New York, New York

**Outside visitors please email celeat@mskcc.org for building access.
You must be on the security list to enter the floor.

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