American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Giovanni Parmigiani
Department of Biostatistics
Harvard University

STATISTICAL ISSUES IN SOMATIC MUTATION STUDIES OF CANCER

The purpose of cancer genome sequencing studies is to determine the nature and types of alterations present in a typical cancer and to discover genes mutated at high frequencies. In the earlier of these studies to investigate the whole genome, about 20 thousand genes were sequenced, using a two-stage design where all genes were sequenced on a discovery set of samples, and then those in which at least one alteration was found were sequenced in an additional validation sample. The two-stage sampling, the rarity of mutations, the varied size and composition of genes, all contribute to generating an interesting and unusual testing ground for statistical methodologies. In this lecture, I will present some of the statistical challenges that arise in these studies, with special emphasis on multiple testing and gene set analysis.


Date: Wednesday, March 16, 2011
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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