American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Marinela Capanu, Ph.D.
Assistant Attending Biostatistician
Memorial Sloan-Kettering Cancer Center

THE USE OF HIERARCHICAL MODELS
FOR ESTIMATING RELATIVE RISKS OF INDIVIDUAL GENETIC VARIANTS

Recent technological progress has led to rapid identification and sequencing of large numbers of genetic variants. Studying the associations between these variants and a particular disease is of great importance to epidemiologists in their quest to decipher the disease etiology. Hierarchical modeling is a technique which has been shown to provide more accurate and stable estimates of individual variants, by incorporating external information through the higher levels of the multilevel model. This talk presents recent research on the application and implementation of hierarchical modeling regression to handle these issues using pseudo-likelihood and Gibbs sampling methods. A real data set from a melanoma case-control study is used to illustrate the methods.

This is joint work with Dr. Colin Begg.


Date: Wednesday, March 21, 2007
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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