American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Benjamin French
Department of Biostatistics and Epidemiology
Perelman School of Medicine
University of Pennsylvania

SEMI-PARAMETRIC ANALYSIS OF BINARY OUTCOMES
IN LONGITUDINAL STUDIES
WITH OUTCOME-DEPENDENT OBSERVATION TIMES

Conventional longitudinal data analysis methods assume that outcomes are independent of the data-collection schedule. However, the independence assumption may be violated, for example, when adverse events trigger additional visits in between prescheduled follow-ups. Outcome-dependent observation times may introduce bias when estimating the effect of covariates on outcomes using a standard longitudinal regression model. Recent research has focused on the development of joint modeling approaches that combine a semi-parametric regression model for a continuous outcome with a recurrent event model for the observation times. One such approach is based on estimating observation-level visit-intensity weights, which are used to reweight the model for longitudinal outcomes. We extend this approach to the analysis of binary outcomes. Computational limitations motivate us to consider a parametric, yet flexible, adjustment for temporal trends in the outcome model. We examine the performance of our methods via simulation studies, and illustrate their application to a randomized controlled trial regarding interventions to improve anti-coagulation control among patients treated with warfarin.


Date: Wednesday, April 3, 2013
Time: 11:00 A.M. - 12:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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