American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Chaya Moskowitz
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

CHOOSE THE NUMBER OF LESIONS TO MEASURE
WHEN EVALUATING TUMOR RESPONSE

The recently revised Response Evaluation Criteria for Solid Tumors (RECIST 1.1) recommends measuring up to a total of five lesions per patient when measuring tumor burden in patients with multiple lesions. This recommendation represents a change from the previous guidelines (RECIST 1.0) which advise measuring up to a total of ten target lesions per patient. There are no existing guidelines which specify the minimum number of lesions that should be measured. In this talk, we will derive an approximation of the distribution for the ratio that quantifies the relative percent change in tumor burden between a baseline and follow-up measurement. We aim to extend this theory to look at the conditional distribution of the relative percent change in tumor burden when a subset of lesions are measured given knowledge of the distribution when all lesions are measured. We can then use the conditional distribution to calculate the sensitivity and specificity of the response assessment based on a subset of lesions. These metrics are familiar to radiologists and clinicians and have the potential to help guide them in their choice of the minimum number of lesions that needs to be measured in a given application.

This is a work in progress done in collaboration with Mithat Gönen.


Date: Wednesday, April 21, 2010
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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