American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
Biostatistics Seminar Series


Irina Ostrovnaya, Ph.D.
Associate Attending
Memorial Sloan Kettering Cancer Center

TESTING TUMORS FROM DIFFERENT ANATOMIC SITES
FOR CLONAL RELATEDNESS USING SOMATIC MUTATION DATA

A common task for the cancer pathologist is to determine, in a patient suffering from cancer, whether a new tumor in a distinct anatomic site from the primary is an independent occurrence of cancer or a metastasis. As mutational profiling of tumors becomes more widespread in routine clinical practice this diagnostic task can be greatly enhanced by comparing the mutational profiles of the tumors to determine if they are sufficiently similar to conclude that the tumors are clonally related, i.e. one is a metastasis of the other. We present here a likelihood ratio test for clonal relatedness in this setting and provide evidence of its validity.

Joint work with Audrey Mauguen, Venkatraman E. Seshan, Colin B. Begg.


Date: Wednesday, April 24, 2019
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor, Conference Room B
New York, New York

**Outside visitors please email koppenar@mskcc.org for building access. You must be on the security list to enter the floor.

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