American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Li Hsu
Department of Biostatistics
University of Washington and Fred Hutchinson Cancer Research Center

ANALYSIS OF GENOMIC INSTABILITY DATA

The integrity and stability of chromosomes enable the cell to transmit accurately its genetic information and function properly physiologically. When aberrations such as rearrangements, deletions and amplifications occur in chromosomes (genomic instability), diseases may arise. In this talk, I will focus on copy number data and the detection of the break points where the changes of copy number occur. To detect the break points, we propose a wavelet-based test statistic taking the maximum of two-scale wavelet coefficient products across scales. I will discuss the statistical inference of this test statistic and show some simulation and real data analysis results.

After breakpoints are identified, the data can be segmented into different states, for example, normal versus aberration state. For simplicity, we represent the segmented data by a series of binary variables. There is ample evidence to show that some of the aberrations co-occur in diseases. Thus, it seems important to find these co-occurrences, as it may help us understand the network in the disease process. If time permits, I will also present a recent work on the sparse regression-based approach for identifying the network using high dimensional binary data.


Date: Wednesday, April 28, 2010
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Page last modified on April 21, 2010

Copyright © 1998-2010 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to nycasa@mindspring.com