American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Terry Speed, Ph.D.
Professor
Department of Statistics
University of California Berkeley
Head, Bioinformatics Division
The Walter and Eliza Hall Institute of Medical Research
Melbourne, Australia

STATISTICAL CHALLENGES WITH NEXT-GENERATION SEQUENCE DATA

Recent improvements in the efficiency, quality, and cost of genome-wide sequencing are prompting biologists to abandon microarrays in favor of next-generation sequencers, e.g., Applied Biosystems' SOLiD, Helicos BioSciences' HeliScope, Illumina's Solexa, and Roche's 454 Life Sciences sequencing systems, and more. These high-throughput sequencing technologies have already been applied to studying genome-wide transcription levels (mRNA-Seq), transcription factor binding sites (ChIP-Seq), chromatin structure, DNA copy number, and DNA methylation status and other topics. This talk, which draws heavily on unpublished work of Sandrine Dudoit and her students, and my student Oleg Mayba, touches on some of these areas, with the major focus being on ChIP-Seq.


Date: Wednesday, May 13, 2009
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Basement Conference Room (NOTE DIFFERENT ROOM)
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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