American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Karen Bandeen-Roche, Ph.D.
Professor
Department of Biostatistics
Johns Hopkins Bloomberg School of Public Health

THE ROLE OF ASSUMPTIONS
IN LATENT VARIABLE MODEL ESTIMATION:
ELUCIDATION AND TUNING

Latent variable models have long been utilized by behavioral scientists to summarize constructs that are represented by multiple measured variables or are difficult to measure, such as health practices and psychiatric syndromes. They have been regarded as particularly useful when variables that can be measured are highly imperfect surrogates for the construct of inferential interest, but they are also criticized as being overly abstract, weakly estimable, and sensitive to unverifiable modeling assumptions. First, my talk reviews methods I have developed for assessing modeling assumptions and delineating what are the targets of parameter estimation in the case of maximum likelihood fitting, allowing for a mis-specified model. Then, it describes new work to counterbalance standard latent variable modeling assumptions focused on internal validity of measurement with alternative assumptions say, focused on external or concurrent validation. Small sample performance properties of the methodology are evaluated. The methods will be illustrated using data on post traumatic stress disorder in a population-based sample and adverse health in older adults. It is hoped that the findings will lead to improved usage of latent variable models in scientific investigations.


Date: Wednesday, May 30, 2007
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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