American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Wenbin Lu
Department of Statistics
North Carolina State University

SELECTION OF PREDICTIVE VARIABLES
FOR OPTIMAL TREATMENT DECISION

In decision-making on optimal treatment strategies, it is of great importance to identify predictive variables that are involved in the decision rule, i.e. those interacting with the treatment. Effective variable selection helps to improve the prediction accuracy and enhance the interpretability of the decision rule. In this talk, I will present a new penalized regression framework which can simultaneously estimate the optimal treatment strategy and identify important variables. The advantages of the new approach include: (i) it does not require the estimation of the baseline mean function of the response, which greatly improves the robustness of the estimator; (ii) the convenient loss-based framework makes it easier to adopt shrinkage methods for variable selection, which greatly facilitates implementation and statistical inferences for the estimator. The new procedure can be easily implemented by existing state-of-art software packages like LARS. I will also present some theoretical properties of the new estimators and show their empirical performance using simulation studies and an application to an AIDS clinical trial.


Date: Wednesday, September 5, 2012
Time: 11:00 A.M. - 12:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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