American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Sean Devlin, Ph.D.
Department of Epidemiology & Biostatistics
Memorial Sloan-Kettering Cancer Center

AN ADAPTIVE METHOD FOR INCORPORATING
NEW GENOMIC MARKERS INTO AN EXISTING PROGNOSTIC CLASSIFIER

Most solid and hematologic malignancies have a prognostication system that helps guide clinical care and patient counseling. For example, TNM staging, consisting of primary tumor characteristics (T), locoregional spread to lymph nodes (N), and distant metastases (M), is commonly used in solid cancers. Similarly, cytogenetic risk, which characterizes the chromosomal abnormalities in the malignant clone, has become standard-of-care for predicting outcome and making therapeutic decisions in many hematologic malignancies. As new genomic marker panels are developed, it is of clinical interest to determine how these markers can help refine and improve the predictive accuracy of an existing classification system. In this talk, we outline a new algorithm for incorporating genomic markers into a classification system and review some initial results.

This is joint work with Irina Ostrovnaya and Mithat Gönen.


Date: Wednesday, September 11, 2013
Time: 10:00 - 11:00 A.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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