American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Francesca Demichelis, Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
Institute for Computational Bioscience
Weill Cornell Medical College

COPY NUMBER ALTERATIONS AND FUSION PROSTATE CANCER

Structural alterations are a major component in the genomic landscape of healthy and unhealthy cells. We are interested in the characterization of copy number alterations with respect to ETS fusion prostate cancer. Emerging molecular and clinical data suggest that ETS fusion prostate cancer represents a distinct molecular subclass, driven most commonly by a hormonally regulated promoter and characterized by an aggressive natural history. To investigate potential genomic components, we performed genome-wide profiling of primary prostate cancers and analyzed recurrent chromosomal copy number aberrations in the light of consistent transcript deregulation. We further characterized genomic areas of interest by designing a custom tiling array with 30 bp resolution. Due to the high prevalence of prostate cancer and its genetic components, we are also investigating the role of copy number variations as risk factor for developing the disease.


Date: Wednesday, September 17, 2008
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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