American Statistical Association
New York City
Metropolitan Area Chapter

Biostatistics Seminar Series
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center



Zhigang Zhang, Ph.D.
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

A SENSITIVITY STUDY OF LATENT FRAILTY TERMS
IN MODELING DEPENDENCE STRUCTURES IN FAILURE TIME DATA

In survival analysis and other areas, when two or more endpoints are correlated or dependent, the data structure is often modeled via unobserved frailty terms. In this study we review recent research results and conduct sensitivity analyses, both numerically and theoretically, to investigate the influence and outcomes of the frailty specification. We show that its stochastic properties, as well as misspecifications, may impact the inferences on parameter estimates in various ways. Both simulation results and real data analysis are presented for illustration.


Date: Wednesday, September 21, 2016
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor
Conference Room B
New York, New York 10017

**Note: Outside visitors please email celeat@mskcc.org, for building access. You must be on the security list to enter the floor.

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