American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



This seminar is CANCELLED due to an unexpected event.
It is being rescheduled and you will be informed once the date is chosen.


Nicholas P. Jewell
Department of Biostatistics
Department of Statistics
University of California at Berkeley

CAUSAL DIAGRAMS AND RCTS?
APPLICATIONS TO SECONDARY INTERVENTIONS AND UNMASKING EFFECTS

Randomization has been long used in therapeutic and intervention trials to form the basis of causal inference regarding treatment effects. The Methods for Improving Reproductive Health in Africa (NIRA) trial, designed to examine the effects of the diaphragm and lubricant gel in reducing sexually transmitted infections, raised issues regarding the standard intention-to-treat analysis due to the role of a secondary intervention on condom use. A further example occurs in the differential use of statins in the RECORD trial examining the safety of Avandia. A similar causal diagram arises in a very different situation involving blinded clinical trials with treatment-related side effects due to the potential for unmasking of treatment assignment. In this case, we motivate and discuss the causal issues based on a randomized, double-blind, placebo-controlled trial of pain medication for patients suffering from diabetic neuropathy.


Date: Wednesday, September 29, 2010 -- CANCELLED
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Basement Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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