American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Xihong Lin
Department of Biostatistics
Harvard School of Public Health

STATISTICAL ISSUES AND CHALLENGES
IN ANALYZING HIGH-THROUGHPUT "OMICS" DATA
IN POPULATION-BASED STUDIES

With the advance of biotechnology, massive "omics" data, such as genomic and proteomic data, become rapidly available in population based studies to study interplay of genes and environment in causing human diseases. An increasing challenge is how to analyze such high-throughput "omics" data, interpret the results, and make the findings reproducible. We discuss several statistical issues in analysis of high-dimensional "omics" data in population based "omics" studies. We present statistical methods for analysis of several types of "omics" data, including incorporation of biological structures in analysis of data from genome-wide association studies, analysis of genetic pathway data and gene selection, and analysis of genome-wide DNA methylation data and study of genes and environment. Data examples are presented to illustrate the methods. Strategies for interdisplinary training in statistical genetics, computational biology and genetic epidemiology will also be discussed.


Date: Wednesday, October 14, 2009
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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