American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Pei Wang, Ph.D.
Associate Professor
Icahn School of Medicine at Mount Sinai

A COVARIANCE-BASED TEST FOR PATHWAY ANALYSIS

The use of high-throughput biological data to study the changing behavior of biological pathways has focused mainly on examining the changes in the means of pathway genes. In this paper, we propose the alternative approach of testing for changes in the pattern of co-regulation of pathway genes, allowing examination of their joint behavior. We assume the eigenvalues of a-priori known pathways capture biologically relevant quantities, and we develop SETPath, a test for relevant changes in the eigenvalues between classes. This test reflects important and often ignored aspects of pathway behavior and provides a useful complement to traditional pathway analyses.


Date: Wednesday, October 15, 2014
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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