American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar


Ying Kuen Ken Cheung, Ph.D.
Assistant Professor
Department of Biostatistics
Mailman School of Public Health
Columbia University

TWO PRACTICAL ISSUES IN DESIGNING PHASE I CANCER TRIALS:
LATE TOXICITIES AND DOSE-TOXICITY MODELING

Traditional designs for phase I clinical trials require each patient (or small group of patients) to be completely followed before the next patient or group is assigned. In situations where late toxicities are important, this may result in trials of impractically long duration. In the first half of the talk, I will introduce the time to event continual reassessment method (TITE-CRM), which allows patients to be entered in a staggered fashion. It is an extension of the continual reassessment method (CRM), a model-based method for phase I trials. We prove that the recommended dose given by the TITE-CRM converges to the correct level under certain conditions. In the second half, I will describe a technique to evaluate the sensitivity of the dose-toxicity model in the CRM. Although the technique is based on asymptotic arguments, we find that it is indicative of when the method will fail in small sample settings.


Date: Wednesday, October 24, 2007
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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