American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
Biostatistics Seminar Series


Rob Strawderman, Sc.D.
Department Chair
Donald M. Foster, MD Distinguished Professor of Biostatistics
University of Rochester

CENSORING UNBIASED SURVIVAL TREES AND FORESTS

Survival trees use recursive partitioning to separate patients into distinct risk groups when some observations are right-censored. Survival forests average multiple survival trees, leading to more flexible and accurate prediction models. Existing algorithms for trees and forests in the case of uncensored outcomes rely heavily on the specification of a loss function (e.g., squared error loss) that governs all aspects of the decision-making process. Existing algorithms for censored outcomes typically bear little resemblance to what is used when censoring is absent. We unify the treatment of these algorithms through the development of a class of censoring unbiased loss functions. We discuss some of the properties of these loss functions and associated practical issues, and extend them for use with competing risks. We further demonstrate how these new algorithms can be implemented using existing software. The performance of the resulting methods is evaluated through simulation studies and, time permitting, illustrated using data from RTOG 9410, a randomized trial of patients with locally advanced inoperable non-small cell lung cancer.

This talk covers some joint work with Jon Steingrimsson,
Youngjoo Cho, Liqun Diao, Chen Hu, and Annette Molinaro.


Date: Wednesday, October 24, 2018
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor, Conference Room B
New York, New York

**Outside visitors please email wernery@mskcc.org for building access.
You must be on the security list to enter the floor.

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