American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Alexia Iasonos
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

ESTIMATING THE DOSE-TOXICITY CURVE IN COMPLETED PHASE I STUDIES

It has been shown previously that the MTD chosen by the standard method (SM) may be low, possibly leading to a non-efficacious dose. Additionally, when deviation from the original trial design occurs, the rules for determining MTD might not be applicable. We hypothesize that a retrospective analysis would suggest a MTD that is more accurate than the one obtained by the SM. In this study, we propose a method to analyze completed phase I trials and possibly amend the recommended Phase II dose, based on constrained maximum likelihood estimation (CMLE). I will present a comparison of CMLE with the retrospective Continual Reassessment Method (O’Quigley 2005) in analyzing simulated SM trials as well as existing trials from Memorial Sloan-Kettering Cancer Center. A framework for estimating confidence intervals around the toxicity probabilities at each dose level will also be presented.

This is joint work with Irina Ostrovnaya.


Date: Wednesday, October 28, 2009
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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