American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar



Ronglai Shen
Department of Epidemiology and Biostatistics
Memorial Sloan-Kettering Cancer Center

INTEGRATIVE CLUSTERING STRATEGY
AND SUBTYPE ANALYSIS IN GLIOBLASTOMAS

The NCI/NHGRI initiated Cancer Genome Atlas (TCGA) project is a coordinated effort to catalogue the entire spectrum of genomic, epigenomic and transcriptomic alterations in the cancer genome. The TCGA network has recently published an interim analysis of DNA copy number, gene expression, DNA methylation aberrations, and mutation profiles of a selected set of cancer genes in 206 glioblastomas. Integrative analysis of multiple high-dimensional genomic data types is a new challenge. Major statistical issues that arise include generalizing dimension reduction to multiple high-dimensional correlated data sets, adjusting for spatial correlation along genomic positions, and modeling the within- and between-data type covariance structures. In this talk, I will introduce a lasso-regularized joint latent variable modeling framework to deal with these issues. Preliminary results of a subtype analysis in the GBM data set will be presented.


Date: Wednesday, November 4, 2009
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.

RESERVATIONS ARE NOT REQUIRED


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