American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
Biostatistics Seminar Series


Elli Papaemmanuil, Ph.D.
Department of Epidemiology & Biostatistics
Memorial Sloan Kettering Cancer Center

CHARACTERIZATION OF SPATIAL AND
TEMPORAL CLONAL PHYLOGENIES IN NEUROBLASTOMA

Neuroblastoma is the most common extracranial solid tumor in children. It accounts for 5% of all pediatric tumor diagnosis but is responsible for 10% of pediatric cancer mortality. The median age of diagnosis is 17 months and importantly 2 in 3 children present with metastatic disease. MYC-N amplification is associated with high-risk disease, metastasis and poor survival (< 40%). Studies aimed towards a better understanding of high-risk neuroblastoma biology, disease progression, gene-treatment interactions and novel therapeutic targets are desperately needed. A brief overview of recent insights from cancer genomics will be presented followed by some early insights into neuroblastoma pathogenesis, disease progression and metastasis using comprehensive whole genome sequencing analysis.


Date: Wednesday, December 14, 2016
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
Conference Room C
New York, New York

**Outside visitors please email Tania at celeat@mskcc.org for building access.
You must be on the security list to enter the floor.

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