American Statistical Association
New York City
Metropolitan Area Chapter

New York State Psychiatric Institute
and Columbia University
Seminar for Biostatistics in Psychiatry



STATISTICAL COST-EFFECTIVENESS ANALYSIS
WITH NET BENEFIT REGRESSION
FROM ESTIMATION AND UNCERTAINTY

by

Jeffrey Hoch, Ph.D.
Department of Health Policy, Management, and Evaluation
University of Toronto


Abstract

The principal aim of this talk is to share lessons learned while conducting three economic evaluations[1], using clinical trial data, of mental health interventions. These lessons are quite general and have clear relevance for many types of studies. In addition, we explore how net benefit regression can be used to enhance consideration of key issues when conducting an economic evaluation based on clinical trial data. The first study we discuss found that cost-effectiveness results varied markedly based on the choice of both the patient outcome and the willingness to pay for more of that outcome. The importance of willingness to pay was also highlighted in the results from the second study. Even with a set willingness-to-pay value, most of the time the probability that the new treatment was cost effective was not 100%. In the third study, the cost effectiveness of the new treatment varied by patient characteristics. Net benefit regression is a useful technique for exploring these crucial issues when undertaking an economic evaluation using patient-level data on both costs and effects.


[1] Hoch, JS, & Dewa, CS. "Lessons from trial-based cost-effectiveness analyses of mental health interventions: why uncertainty about the outcome, estimate and willingness to pay matters." Pharmacoeconomics. 2007; 25(10):807-16.

Biographical Note

Jeffrey Hoch received his Ph.D. in health economics from the Johns Hopkins School of Public Health. He also holds a Masters in Economics from Johns Hopkins University, and a Bachelor of Arts degree in Quantitative Economics and Decision Sciences from the University of California at San Diego. An award winning teacher, Dr. Hoch has taught Health Economics and Economic Evaluation classes in Canada, the United States and internationally. In 2007, he was asked to develop and direct the Pharmacoeconomics Research Unit at Cancer Care Ontario. As Director of the unit, Dr. Hoch has pursued research making health economics more useful to decision makers. Special interests include health services research related to cancer, mental health, and other health issues affecting poor and vulnerable populations.


Date: Tuesday, March 27, 2012
Time: 3:30 - 4:30 P.M.
Location: New York State Psychiatric Institute
1051 Riverside Drive
6th Floor Multipurpose Room (6602)
New York, New York
(Directions)

RESERVATIONS ARE NOT REQUIRED

Coffee: 3:00 to 3:30 P.M.
Informal Reception: 4:30 to 5:00 P.M.


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