American Statistical Association
New York City
Metropolitan Area Chapter

New York State Psychiatric Institute
at Columbia University Medical Center
Biostatistics Seminar



DEALING WITH BIAS IN THE MTA FOLLOW-UP STUDY

by

Sue Marcus, Ph.D.
Assistant Professor
Department of Psychiatry
Mount Sinai School of Medicine


Abstract

The Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA) randomized a group of 579 children with ADHD, aged 7 to 9.9 years, to 14 months of medication management, intensive behavioral treatment, the two combined or standard community care. The sample was also followed in a naturalistic longitudinal design for a total of 8 years (to 15 to 18 years). The MTA Study provides a rich source of evidence to assess the long-term effectiveness of medication for children with ADHD. However, bias due to treatment switching must be addressed. It was hypothesized that the association of ADHD symptom severity and long-term medication use would result in selective long-term treatment of the most severe cases, which could mask the potentially beneficial long-term effects of the medication. We show how to specify propensity score matching to balance longitudinal comparisons and present our findings with the 36-month MTA Follow-up data.

Biographical Note

Sue M. Marcus is Assistant Professor of Psychiatry and Mathematics in the Department of Psychiatry of the Mount Sinai School of Medicine. She received an M.S. in Biostatistics from Harvard School of Public Health and a Ph.D. in Statistics from the Wharton School of the University of Pennsylvania where she did her dissertation under the supervision of Paul Rosenbaum. Dr. Marcus has written and consulted extensively on observational study methods for bias in longitudinal mental health studies. Dr. Marcus is a Research Scientist at the Center for Health Statistics at the University of Illinois at Chicago, a leading center for the development of statistical methods for causal inference in longitudinal studies. She has been a Scientific Advisor to the NIMH multisite TADS trial and statistical consultant for the NIMH multisite Multimodal Treatment for Children with ADHD (MTA) Follow-up Study.


Date: Wednesday, April 1, 2009
Time: 1:30 - 2:30 P.M.
Location: New York State Psychiatric Institute
1051 Riverside Drive
Auditorium (New PI Building)
New York, New York
(Directions)

RESERVATIONS ARE NOT REQUIRED

Coffee will be served.


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