American Statistical Association
New York City
Metropolitan Area Chapter

New York State Psychiatric Institute
at Columbia University Medical Center
Biostatistics Seminar



BIOMARKER RESEARCH AND PERSONALIZED MEDICINE

by

Edwin van den Oord, Ph.D.
Professor & Director, Center for Biomarker Research and Personalized Medicine
Virginia Institute for Psychiatric and Behavioral Genetics
Schools of Pharmacy and Medicine
Medical College of Virginia of Virginia Commonwealth University


Abstract

High-dimensional investigations where (hundreds of) thousands of genotypes, transcripts, methylation markers, and metabolites are measured together with environmental risk factors and clinical information offer great promise to improve the understanding and treatment of psychiatric and substance use disorders. However, to realize the full potential of such investigations, we will need to improve our ability to extract meaningful information from these large data sets and learn how to use results in clinical settings to improve treatment. In this presentation, several key challenges will be addressed. Concrete topics include the control of false discoveries, optimizing study designs and replication efforts, data integration, and the use of genetic variants to individualize drug treatment. The methods will be demonstrated using empirical data from (genomewide) association, methylation, and metabolomics studies.

Biographical Note

Dr. Edwin van den Oord was trained in applied statistics and psychiatric genetics. He is currently a tenured professor at Virginia Commonwealth University where he directs the Center for Biomarker Research and Personalized Medicine. His research aims to develop and apply methodology for identifying biomarkers to improve disease understanding and match individual patients to the most effective and safe medication. High-dimensional investigations where (hundreds of) thousands of genotypes, transcripts, methylation markers, and metabolites are measured together with environmental risk factors and clinical information are considered to be an important research tool. The main applications involve psychiatric and substance use disorders. This research is currently funded by nine grants, where Dr. van den Oord is the principal investigator on four of those grants. He serves on several advisory committees, is publishing 10-15 peer reviewed papers per year, and received a number of awards such as the 2002 Fulker award for the most outstanding paper of the year in the journal Behavior Genetics.


Date: Wednesday, April 29, 2009
Time: Presentation: 11:00 A.M. - 12:00 P.M.
Discussion: 12:00 P.M. - 12:30 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Biostatistics Computer Lab
6th Floor - Room 656
New York, New York

RESERVATIONS ARE NOT REQUIRED

Coffee will be served.


Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Copyright © 2009 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to nycasa@mindspring.com