American Statistical Association
New York City
Metropolitan Area Chapter

Weill Cornell Medical College
Division of Biostatistics & Epidemiology,
Department of Public Health
Research Seminar



ON THE ESTIMATION OF THE INCIDENCE AND PREVALENCE
IN A TWO-PHASE LONGITUDINAL SAMPLING DESIGN

by

Samiran Ghosh, Ph.D.
Senior Biostatistician
Office of Health Outcomes Research
Winthrop University Hospital (SUNY)


Abstract

Two-phase sampling design is a common practice in many medical studies with rare disorders. Generally, the first-phase classification is fallible but relatively cheap, while the accurate second-phase state of-the-art medical diagnosis is complex and rather expensive to perform. When constructed efficiently it offers great potential for higher true case detection as well as for higher precision. In this talk, we consider epidemiological studies with two-phase sampling design. However, instead of a single two-phase study we consider a scenario where a series of two-phase studies are done in longitudinal fashion. Efficient and simultaneous estimation of prevalence as well incidence rate are being considered at multiple time points from a sampling design perspective. Simulation study is presented to measure accuracy of the proposed estimation technique under many different circumstances. Finally, proposed method is applied to a population of elderly adults for the prognosis of major depressive disorder.


Date: Monday, November 14, 2011
Time: 12:00 - 1:00 P.M.
Location: Weill Cornell Medical College
Department of Public Health's Conference Center A
402 East 67th Street
Concourse Level C1
New York, New York

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